This comes courtesy of BuzzFeed, and it’s a keeper. We actually recognized a couple of the words and suspect that some of our brainier readers (who toss around Avogadro’s number) might as well.
The two we were familiar with were aglet (also known as “eyelet”) and meniscus.
You might also want to test your word power with the following: syzygy, darkle, Higbee button, and — courtesy of the website Luciferous Logolepsy — skirr, epicaricacy, and schizothemia.