New cancer vaccine triggers fierce immune response to fight malignant brain tumor

New cancer vaccine triggers fierce immune response to fight malignant brain tumor

A new mRNA cancer vaccine triggers a strong immune response to fight malignant brain tumor, according to a May 1 report in the journal Cell.

An “mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system to attack glioblastoma, the most aggressive and lethal brain tumor,” reports a medical news site:

The results mirror those in 10 pet dog patients suffering from naturally occurring brain tumors whose owners approved of their participation, as they had no other treatment options, as well as results from preclinical mouse models. The breakthrough now will be tested in a Phase I pediatric clinical trial for brain cancer… the discovery represents a potential new way to recruit the immune system to fight notoriously treatment-resistant cancers using…mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions, like a bag full of onions,” said senior author Elias Sayour, M.D., Ph.D….who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign. “And the reason we’ve done that in the context of cancer is these clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method, delivered intravenously, spurred a vigorous immune-system response to reject the tumor…”In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—immune cold, very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said. “That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response.”

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. The current standard of care involves surgery, radiation and some combination of chemotherapy….

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 139 days, compared with a median survival of 30 to 60 days typical for dogs with the condition.

The next step…will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase II.

Another recently developed cancer vaccine for dogs doubles their survival rate.

A child recently was cured of a type of brain cancer that previously always killed kids who had it.

Scientists have developed tiny robots made of human cells to repair damaged cells. Nanorobots are also being used to fight cancer: “In a major advancement in nanomedicine, Arizona State University scientists…have successfully programmed nanorobots to shrink tumors by cutting off their blood supply.”

“Surgeons and scientists have developed a world-first blood test for brain cancer that experts say could revolutionize diagnosis, speed up treatment and boost survival rates.” Despite advances in fighting other kinds of cancer, “brain tumors have remained notoriously difficult to diagnose. They affect hundreds of thousands of people worldwide each year, and kill more children and adults under the age of 40 … than any other cancer.

Robots may also help remove brain cancers. Robots can fit in small spaces in people’s bodies that a surgeon can’t reach without cutting through living tissue.

Scientists recently discovered a new antibiotic that can kill drug-resistant bacteria.

A virus is being used to cure deafness in new gene therapy. Researchers also discovered that a plant virus could be used to save crops from root-eating pests.

Recently, a treatment was discovered for sleeping sickness, a disease that kills 50,000 to 500,000 people per year.

Doctors overseas are using artificial intelligence to detect cases of breast cancer more effectively. Artificial intelligence is now developing highly-effective antibodies to fight disease.

LU Staff

LU Staff

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