Genetically modified Mensa mice may help sufferers from Alzheimer’s, PTSD

Genetically modified Mensa mice may help sufferers from Alzheimer’s, PTSD

Scientists have genetically modified mice to be super-intelligent and found they are also less anxious, a discovery that may help the search for treatments for disorders such as Alzheimer’s, schizophrenia and post traumatic stress disorder (PTSD).

Researchers from Britain and Canada found that altering a single gene to block the phosphodiesterase-4B (PDE4B) enzyme, which is found in many organs including the brain, made mice cleverer and at the same time less fearful.

“Our work using mice has identified phosphodiesterase-4B as a promising target for potential new treatments,” said Steve Clapcote, a lecturer in pharmacology at Britain’s Leeds University, who led the study. …

In the experiments, published on Friday in the journal Neuropsychopharmacology, the scientists ran a series of behavioral tests on the PDE4B-inhibited mice and found they tended to learn faster, remember events longer and solve complex problems better than normal mice.

The “brainy” mice were better at recognizing a mouse they had seen the previous day, the researchers said, and were also quicker at learning the location of a hidden escape platform.

Continue reading →

For your convenience, you may leave commments below using either the Spot.IM commenting system or the Facebook commenting system. If Spot.IM is not appearing for you, please disable AdBlock to leave a comment.


Commenting Policy

We have no tolerance for comments containing violence, racism, profanity, vulgarity, doxing, or discourteous behavior. If a comment is spam, instead of replying to it please hover over that comment, click the ∨ icon, and mark it as spam. Thank you for partnering with us to maintain fruitful conversation.