Nathan, born Nancy, Verhelst, 44, was given legal euthanasia, most likely by lethal injection, on the grounds of “unbearable psychological suffering” on Monday afternoon.
Wim Distelmans, a cancer specialist who carried out the euthanasia, is the same doctor who late last year gave lethal injections to congenitally deaf twins who were frightened they were also going blind.
“I was the girl that nobody wanted,” Mr Verhelst told Het Laatste Nieuws newspaper in the hours before her death.
“While my brothers were celebrated, I got a storage room above the garage as a bedroom. ‘If only you had been a boy’, my mother complained. I was tolerated, nothing more.”
Mr Verhelst had hormone therapy in 2009, followed by a mastectomy and surgery to construct a penis in 2012. But “none of these operations worked as desired”.