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The natural progress of things is for liberty to yield and government to gain ground. —THOMAS JEFFERSON, 1788

Ugh! Fecal transplants to treat intestinal infections

Boston Globe

The half-century old medical procedure has long been a measure of last resort, its mere mention enough to make a room full of doctors wrinkle their noses and laugh like schoolchildren: When a patient suffers from a gastrointestinal infection that keeps coming back, try transplanting someone else’s feces into the gut to restore a normal balance of healthy bacteria.

The scatological treatment may seem more medieval than modern, but over the past decade, doctors have increasingly stopped snickering and started to try it –with promising results. There is now a flurry of new trials at cutting-edge medical centers in Boston and elsewhere, and on Wednesday, a rigorous randomized trial published by Dutch researchers found that most patients with serious, recurrent infections caused by the bacteria C. difficile got better when donor feces were infused into their intestines. That study was halted early because the patients fared so much better than a group given standard antibiotic therapy.

“There’s an aesthetic factor. There’s a gross factor that wigs people out a little bit,” said Dr. George Russell, a pediatric gastroenterologist at Massachusetts General Hospital who did his first fecal transplant in 2010, on a two-year-old child with a relapsing C. difficile infection. “But I think people get over it, and it makes sense to them intuitively.”

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